Makoto Honda Selected Research

Cataplexy

1/2020	Epigenome-wide association study of narcolepsy-affected lateral hypothalamic brains, and overlapping DNA methylation profiles between narcolepsy and multiple sclerosis.
12/2018	A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia.
1/2017	Steroid therapy ameliorated cataplexy in three children with recent-onset of narcolepsy.
2/2015	New susceptibility variants to narcolepsy identified in HLA class II region.
1/2015	An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.
6/2014	Challenges in diagnosing narcolepsy without cataplexy: a consensus statement.
9/2013	Passive transfer of narcolepsy: anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice.
1/2013	Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
2/2012	Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: comparison between patients on psychostimulants, drug-naïve patients and the general Japanese population.
7/2010	Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy.

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Makoto Honda Research Topics

Disease

34	Narcolepsy 10/2022 - 05/2006
19	Cataplexy 01/2020 - 05/2006
11	Disorders of Excessive Somnolence (Hypersomnia) 10/2022 - 12/2008
8	Sleep Wake Disorders 01/2020 - 06/2007
6	Idiopathic Hypersomnia 04/2022 - 12/2008
4	Sleepiness 01/2013 - 05/2006
1	Apnea 11/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2016
1	Respiratory Tract Diseases (Respiratory Tract Disease) 08/2014
1	Infections 08/2014
1	Schizophrenia (Dementia Praecox) 05/2002
1	Atherosclerosis 03/2002

Drug/Important Bio-Agent (IBA)

13	OrexinsIBA 06/2022 - 05/2006
9	HLA Antigens (Human Leukocyte Antigens)IBA 05/2019 - 08/2007
9	HLA-DQB1 antigen (HLA DQB1)IBA 12/2018 - 05/2008
6	HLA-DRB1 Chains (HLA DRB1)IBA 10/2015 - 05/2006
4	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 10/2022 - 03/2011
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 10/2016 - 06/2009
4	AutoantibodiesIBA 09/2013 - 05/2006
3	Fatty Acids (Saturated Fatty Acids)IBA 10/2022 - 03/2011
3	Immunoglobulin G (IgG)IBA 01/2017 - 03/2010
2	Purinergic Receptors (Receptors, Purine)IBA 10/2016 - 01/2011
2	CytokinesIBA 08/2014 - 08/2007
2	NeuropeptidesIBA 05/2014 - 01/2009
2	AntibodiesIBA 09/2013 - 03/2002
2	acylcarnitineIBA 01/2013 - 03/2011
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2013 - 03/2011
2	Pharmaceutical PreparationsIBA 02/2012 - 12/2008
2	Genetic Markers (Genetic Marker)IBA 01/2010 - 01/2009
2	Orexin ReceptorsIBA 08/2008 - 05/2006
1	5'-methylthioadenosineIBA 11/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Biological ProductsIBA 05/2019
1	Unithiol (DMPS)IBA 01/2018
1	Hormones (Hormone)IBA 01/2018
1	AcidsIBA 01/2018
1	CXCR3 ReceptorsIBA 01/2017
1	SteroidsIBA 01/2017
1	GTP-Binding Proteins (G-Protein)IBA 10/2016
1	Presenilin-1IBA 01/2016
1	CC ChemokinesIBA 10/2015
1	InterleukinsIBA 08/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2014
1	Interleukin-6 (Interleukin 6)IBA 08/2014
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 08/2014
1	Interleukin-8 (Interleukin 8)IBA 08/2014
1	Biomarkers (Surrogate Marker)IBA 06/2014
1	SynaptophysinIBA 09/2013
1	EnzymesIBA 01/2013
1	Messenger RNA (mRNA)IBA 03/2011
1	3' Untranslated Regions (3' UTR)IBA 01/2011
1	AntigensIBA 07/2010
1	HLA-DR2 Antigen (HLA DR2 Antigen)IBA 06/2009
1	LigandsIBA 08/2008
1	Ataxin-3IBA 08/2008
1	RNA (Ribonucleic Acid)IBA 08/2007
1	BenzodiazepinesIBA 05/2002
1	Scavenger Receptors (Scavenger Receptor)IBA 03/2002

Therapy/Procedure

2	Therapeutics 01/2017 - 08/2008
1	Drug Therapy (Chemotherapy) 06/2007